Mike Kappelman, MD, MPH Principal Investigator, COMBINE
Dr. Michael D. Kappelman, MD, MPH is the a pediatric gastroenterologist at the University of North Carolina at Chapel Hill with an interest in the clinical care of children and young adults with inflammatory bowel disease. He also devotes considerable effort to quality improvement and epidemiological and outcomes research in this area. This includes studies of the prevalence, natural history, costs, and utilization of resources by children and adults with IBD, as well patient centered outcomes research and comparative effectiveness and safety research.
Dr. Kappelman is the Chair of the Pediatric Affairs Committee for the Crohn’s and Colitis Foundation of America and serves on the National Scientific Advisory Council. He alsoholds a number of leadership roles within ImproveCareNow, including serving on the network’s Strategy Council, Physician Leadership Group, and Data Management Division.
Peter Margolis, MD, PhD Principal Investigator, ICN
Peter Margolis, MD, PhD is the Co-Director of the James M. Anderson Center for Health Systems Excellence at Cincinnati Children’s Hospital Medical Center and the Professor of Pediatrics at the University of Cincinnati. Dr. Margolis’ work encompasses the application and study of quality improvement methods in a broad range of areas including primary and sub-specialty care, communities and public health settings to improve the health outcomes of children, families and communities. In 2006, he joined Cincinnati Children’s Hospital Medical Center to create a new center focused on Health Care Quality. Dr. Margolis has worked extensively with the certifying Boards and Specialty Societies to assist them in designing programs that will enable physicians to meet new Maintenance of Certification requirements focused on systems thinking and performance in practice. He is principle investigator of an NIH Roadmap transformative research grant on redesigning systems for chronic illness care, as well as grants from the Agency For Healthcare Research and the Patient-Centered Outcomes Research Institute aimed at developing learning health systems and transforming the infrastructure for research in the US. He currently serves as the Chair of the PCORNet Steering Committee.
Athos Bousvaros MD, MPH is a pediatric gastroenterologist who has worked at Boston Children’s Hospital for over 25 years. He completed his undergraduate degree at Williams College, his medical degree and residency at Duke University, and his gastroenterology fellowship at Boston Children's Hospital, Massachusetts General Hospital, and Harvard Medical School. As Associate Director of the Inflammatory Bowel Disease program at Boston Children's Hospital, he spends much of his time treating complex cases of Crohn’s disease and ulcerative colitis referred from across the country. His research interests include identifying the cause of IBD by studying the intestinal microbiome, developing new therapies for IBD, and examining the immune response of IBD patients to immunizations. He has over 100 original and review publications in medical literature.
He has served as Chair of the Chapter Medical Advisory Committee of the New England Crohn’s and Colitis Foundation of America and Chair of the CCFA Pediatric Affairs committee. He has also served as President of the North American Society for Pediatric GI and Nutrition (NASPGHAN), where he helped lead a campaign to promote child safety by getting high powered magnets out of the hands of toddlers. When not busy caring for patients or doing research, he enjoys developing patient education materials for children with chronic illness. These include the medical comics: “Pete Learns All About Crohn’s and Colitis” (with the CCFA), “Amy Goes Gluten Free,” “JD Shapes Up,” and “Sophie’s Science Project.” He has also co-authored the NASPGHAN book “Your Child with Inflammatory Bowel Disease.
Dr. Colletti is a pediatric gastroenterologist and Professor of Pediatrics at the University of Vermont College of Medicine. As the President and Executive Network Director of ImproveCareNow, he is actively engaged in quality improvement and research in pediatric Crohn’s disease and ulcerative colitis. He has been the President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), on the Board of Directors of the Children’s Digestive Health and Nutrition Foundation, and Secretary-Treasurer of the Federation of International Societies for Pediatric Gastroenterology, Hepatology and Nutrition. He is a graduate of the University of Pittsburgh School of Medicine and completed his residency at Yale University and his fellowship at Texas Children’s Hospital, Houston. He has co-authored over 100 papers, book chapters and monographs, and has given over 140 national and international presentations.
Dr. Anastasia Ivanova has been on faculty at UNC-Chapel Hill since 1999. Her main research area is design and analysis of clinical trials including adaptive and Bayesian trials. These and other topics are covered in the clinical trials course she has been teaching since 2007.
Dr. King has provided biostatistical leadership in the design, analysis, and interpretation of results from animal and human clinical research studies supporting drug discovery, early and late stage drug development, commercialization, and market support. She provided statistical expertise and oversight for the development, review, and defense of 10 new drug application submissions in the areas of gastrointestinal, cardiac, bone diseases and female sexual health. She is currently leading the growing Data Management Center to assure appropriate data management processes for data collection, data cleaning and validation, and data finalization, documentation and archival are used which lead to high quality data that can be shared with the research community at large.
Dr. King is active in the American Statistical Association and is currently chair of the Council of Sections Governing Board. She is an associate editor for the Journal of Statistical Education. Dr. King mentors junior faculty, staff and students in DBE and Gastroenterology and the Anderson Center. She is the primary instructor of “Statistical Principles for Clinical Research Studies” in the UC College of Pharmacy.
Dr. Keith Marsolo is an associate professor in the Division of Biomedical Informatics within the UC Department of Pediatrics whose research interests include methods to characterize the quality and suitability of electronic health record (EHR) data, approaches to collect and extract research data from the EHR at scale, the design and instantiation of common data models to facilitate distributed research queries, and the development of informatics architectures and standards that can support multi-center learning health systems. He serves as faculty advisor for BMI Data Services, which has specialized expertise in these areas.
Dr. Marsolo led the implementation of Cincinnati Children's research data warehouse, which utilizes a custom version of the open-source i2b2 framework, allowing users to perform de-identified cohort queries. Dr. Marsolo and his team have developed several other stand-alone applications that interface with the EHR, including a tool that supports Cincinnati Children's research biobank. Dr. Marsolo and his team are also heavily involved in development of systems to support multi-center learning health systems, and in using EHR data to instantiate common data models that can be queried through distributed research networks. Dr. Marsolo and his team successfully completed an extension grant from the Agency for Healthcare Research and Quality that builds on their previous implementation of an EHR-linked registry for ImproveCareNow. Dr. Marsolo and his team are also involved in the implementation of PCORI’s National Patient-Centered Clinical Research Network (PCORnet). They are participating in a pediatric-focused Clinical Data Research Network (CDRN), and a Patient-Powered Research Network (PPRN) with ImproveCareNow. Dr. Marsolo also served as one of the co-chairs of the PCORnet’s Data Standards, Security and Network Infrastructure (DSSNI) Task Force during the first phase of PCORnet.
Shehzad Saeed, MD graduated from Dow Medical College, University of Karachi, Pakistan in 1991. He then moved to the US to pursue postgraduate training serving his pediatric residency at The University of Chicago Children’s Hospital and pediatric gastroenterology fellowship at Floating Hospital for Children, Tufts University under the mentorship of Richard J Grand, MD. After finishing his training, he moved to Greenville, South Carolina and then the University of Alabama at Birmingham as junior faculty member. He assumed the GI fellowship director role in 2005, and then became the division director in 2006. He assumed the role of the Clinical Director of the Schubert-Martin Pediatric IBD Center at Cincinnati Children’s Hospital Medical Center from 2010 till 2016 and has served as Clinical Director of GI as well as the Medical Director of the inpatient GI/Colorectal unit, as well as Director, GI Outpatient Operations, Liberty Campus, Cincinnati Children’s Hospital. He has joined the division of Gastroenterology at Dayton Children Hospital in July 2016, and will be serving as the Chief Medical Value Based Care Officer of the hospital, spearheading development of value based care and a clinically integrated network for the hospital.
Dr. Saeed research and administrative focus is outcomes of children with IBD, Quality Improvement in IBD as well as the GI division. He serves on the Physician Leadership Group as well as Clinical Practice Committee for the ImproveCareNow network, a national QI collaborative for children with IBD and also serves as Associate Physician for Innovation. He has also worked closely with the Anderson Center for Health System Excellence at Cincinnati Children’s Hospital Medical Center to develop and implement prototypes on patient engagement, N of 1 trials/personalized learning systems, patient reported outcomes, eVisits, and mentoring.
Morris is a health services researcher who develops and evaluates innovative strategies to improve the process and outcomes of care for patients with chronic diseases. Most of his research has been conducted with socioeconomically and/or medically vulnerable patients, including Veterans. The strategies have been designed to be implemented within health care systems should they demonstrate effectiveness as measured by clinical parameters, health services utilization/costs, and patient-centered outcomes.
He has received several national awards that recognize his accomplishments as a researcher, including the Under Secretary's Award for Outstanding Achievement in Health Services Research from the Department of Veterans Affairs (2003) and the Vision Award for Groundbreaking Research in Chronic Illness Care from the Robert Wood Johnson Foundation (2002).
Morris is also committed to mentoring students, fellows and junior faculty. He is Director of our PhD program and is co-Director of the Education Service for NC TraCS at UNC. He has also received numerous awards for his advising and mentoring, including the Class of 1996 Award for Advising Excellence from UNC (2015), the John E. Larsh, Jr Award for Mentorship from the UNC Gillings School of Global Public Health (2013), and the John M. Eisenberg Excellence in Mentorship Award from AHRQ (2005).
David Wohl’s son, Zac, has lived with Crohn’s disease since he was 5 years old. He joined the ImproveCareNow (ICN) Parent Working Group in 2012 and directs its Research Subcommittee. At the University of North Carolina in Chapel Hill, where Zac receives IBD care, David founded the IBD Parent Advocacy Group, which aims to support and assist the clinic to provide high-quality care to its young patients. David co-leads the COMBINE Trial Engagement Team.
Lisa Pitch’s son was diagnosed with Crohn’s Disease when he was 10 years old. They both feel fortunate that his clinic, Pediatric Gastroenterology and Nutrition Associates (PGNA), is a participating ImproveCareNow center. Since then, Lisa has become a member of ICN’s Parent Working Group (PWG), and is also a member of the PWG Research Subcommittee. In addition, she is a member of the ICN Research Committee, and is on the Engagement Team for both the COMBINE Trial, and the Patient Centered Outcomes Research Institute’s (PCORI) funded Healthy Mind, Healthy You Study.
Mr. Egües currently serves as Co-President of Shelton Vineyards, Inc., North Carolina’s largest estate Winery, a position he has had since 2012. He has over 28 years of experience investing in and working with private and public Companies. In 2004 he founded Triarch Capital Partners LLC, a middle market focused mergers and acquisitions boutique based in Charlotte, NC. His experience includes having worked with Williamson Investors L.P., a Charlotte based hedge fund as a portfolio manager, and for the Shelton Companies, Inc., a private investment company. He began his investment career with First Union Capital Partners, where he worked for eight years making mezzanine and equity investments. Mr. Egües graduated from the University of North Carolina at Chapel Hill as a Morehead Scholar with a Bachelor of Arts degree in Economics. He is President of the Carolina’s Chapter of the Crohn’s and Colitis Foundation of America. Mr. Egues was a member of the Board of the St. Peters Episcopal Church Endowment in Charlotte and has served as a member of the Board of Trustees of the North Carolina School of Science and Mathematics in Durham, North Carolina.